The C. elegans glycosyltransferase BUS-8 has two distinct and essential roles in epidermal morphogenesis.

Journal article

Ventral enclosure in Caenorhabditis elegans involves migration of epidermal cells over a neuroblast substrate and subsequent adhesion at the ventral midline. Organisation of the neuroblast layer by ephrins and their receptors is essential for this migration. We show that bus-8, which encodes a predicted glycosyltransferase, is essential for embryonic enclosure and acts in or with ephrin signalling to mediate neuroblast organisation and to permit epidermal migration. BUS-8 acts non-cell-autono...

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Authors: Partridge, F; Tearle, A; Gravato-Nobre, M; Schafer, W; Hodgkin, J

• Publication status: Published
• Journal: Developmental biology
• Volume: 317
• Issue: 2
• Pages: 549-559
• Publication date: 2008-05-01
• DOI: 10.1016/j.ydbio.2008.02.060
• EISSN: 1095-564X
• ISSN: 0012-1606
• Language: English
• Keywords: Signal Transduction; Cloning, Molecular; Mutagenesis; Animals; Ephrins; Gene Components; Green Fluorescent Proteins; Microscopy, Electron; Glycosyltransferases; Morphogenesis; Caenorhabditis elegans Proteins; Caenorhabditis elegans; Epidermis