Journal article
Enantioselective desymmetrization of prochiral cyclohexanones by organocatalytic intramolecular Michael additions to α,β-unsaturated esters
- Abstract:
-
A new catalytic asymmetric desymmetrization reaction for the synthesis of enantioenriched derivatives of 2-azabicyclo[3.3.1]nonane, a key motif common to many alkaloids, has been developed. Employing a cyclohexanediamine-derived primary amine organocatalyst, a range of prochiral cyclohexanone derivatives possessing an α,β-unsaturated ester moiety linked to the 4-position afforded the bicyclic products, which possess three stereogenic centers, as single diastereoisomers in high enantioselectiv...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
European Commission
More from this funder
Funded Access
More from this funder
EPSRC
More from this funder
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Angewandte Chemie Journal website
- Volume:
- 54
- Issue:
- 16
- Pages:
- 4899–4903
- Publication date:
- 2015-04-07
- DOI:
- ISSN:
-
1521-3773 and 1433-7851
- Pmid:
-
25727215
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:509932
- UUID:
-
uuid:6aca3459-892a-48ea-ab86-d2128a6f112b
- Local pid:
- pubs:509932
- Deposit date:
- 2016-09-06
Terms of use
- Copyright holder:
- Adam Gammack Yamagata et al
- Copyright date:
- 2015
- Notes:
- This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
If you are the owner of this record, you can report an update to it here: Report update to this record