Journal article
Pharmacokinetics and pharmacodynamics of intensive antituberculosis treatment of tuberculous meningitis
- Abstract:
-
The most effective antituberculosis drug treatment regimen for tuberculous meningitis is uncertain. We conducted a randomized controlled trial comparing standard treatment with a regimen intensified by rifampin 15 mg/kg and levofloxacin for the first 60 days. The intensified regimen did not improve survival or any other outcome. We therefore conducted a nested pharmacokinetic/pharmacodynamic study in 237 trial participants to define exposure–response relationships that might explain the trial...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Wellcome Trust
More from this funder
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Clinical Pharmacology and Therapeutics Journal website
- Volume:
- 107
- Issue:
- 4
- Pages:
- 1023-1033
- Publication date:
- 2020-02-29
- Acceptance date:
- 2020-01-13
- DOI:
- EISSN:
-
1532-6535
- ISSN:
-
0009-9236
- Pmid:
-
31956998
Item Description
- Language:
- English
- Pubs id:
-
1086122
- Local pid:
- pubs:1086122
- Deposit date:
- 2020-06-16
Terms of use
- Copyright holder:
- Ding et al.
- Copyright date:
- 2020
- Rights statement:
- © 2020 The Authors. Clinical Pharmacology & Therapeutics published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record