Impact of study design on recruitment of patients to a primary care trial: an observational time series analysis of the Birmingham Atrial Fibrillation Treatment of the Aged (BAFTA) study.
BACKGROUND: recruitment targets to randomized controlled trials (RCTs) are often not met. Many interventions are used to improve recruitment but there is little empirical evidence on whether these approaches work. OBJECTIVE: to examine whether changes to the design and conduct of a primary care-based RCT were associated with changes in patient recruitment. METHODS: an observational time series analysis of recruitment to a primary care-based multi-centre RCT of aspirin versus warfarin for str...Expand abstract
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