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Genome-wide analysis identifies a role for common copy number variants in specific language impairment.

Abstract:

An exploratory genome-wide copy number variant (CNV) study was performed in 127 independent cases with specific language impairment (SLI), their first-degree relatives (385 individuals) and 269 population controls. Language-impaired cases showed an increased CNV burden in terms of the average number of events (11.28 vs 10.01, empirical P=0.003), the total length of CNVs (717 vs 513 Kb, empirical P=0.0001), the average CNV size (63.75 vs 51.6 Kb, empirical P=0.0005) and the number of genes spa...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ejhg.2014.296

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More from this funder
Name:
Wellcome Trust
Grant:
076566
More from this funder
Name:
Medical Research Council
Grant:
MR/J003719/1
More from this funder
Name:
National Institute for Health Research, Oxford Biomedical Research Centre
Publisher:
Nature Publishing Group
Journal:
European journal of human genetics : EJHG More from this journal
Volume:
23
Issue:
10
Pages:
1370-1377
Publication date:
2015-10-01
DOI:
EISSN:
1476-5438
ISSN:
1018-4813
Language:
English
Keywords:
Pubs id:
pubs:503556
UUID:
uuid:6abd09e5-d5ba-4000-b317-a6ac2dacf2d7
Local pid:
pubs:503556
Source identifiers:
503556
Deposit date:
2015-01-28

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