Journal article
Genome-wide analysis identifies a role for common copy number variants in specific language impairment.
- Abstract:
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An exploratory genome-wide copy number variant (CNV) study was performed in 127 independent cases with specific language impairment (SLI), their first-degree relatives (385 individuals) and 269 population controls. Language-impaired cases showed an increased CNV burden in terms of the average number of events (11.28 vs 10.01, empirical P=0.003), the total length of CNVs (717 vs 513 Kb, empirical P=0.0001), the average CNV size (63.75 vs 51.6 Kb, empirical P=0.0005) and the number of genes spa...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 390.3KB)
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- Publisher copy:
- 10.1038/ejhg.2014.296
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Authors
Funding
Max Planck Society
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European Research Council
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National Institute for Health Research, Oxford
Biomedical Research Centre
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- European journal of human genetics : EJHG Journal website
- Volume:
- 23
- Issue:
- 10
- Pages:
- 1370-1377
- Publication date:
- 2015-10-01
- DOI:
- EISSN:
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1476-5438
- ISSN:
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1018-4813
- Source identifiers:
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503556
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:503556
- UUID:
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uuid:6abd09e5-d5ba-4000-b317-a6ac2dacf2d7
- Local pid:
- pubs:503556
- Deposit date:
- 2015-01-28
Terms of use
- Copyright holder:
- Macmillan Publishers Limited
- Copyright date:
- 2015
- Notes:
- Copyright © 2015 Macmillan Publishers Limited. This work is licensed under a Creative Commons Attribution 3.0 Unported License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/.
- Licence:
- CC Attribution (CC BY)
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