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Journal article

Mechanisms underlying decision-making as revealed by deep-brain stimulation in patients with Parkinson's disease

Abstract:

To optimally balance opposing demands of speed and accuracy during decision-making, we must flexibly adapt how much evidence we require before making a choice. Such adjustments in decision thresholds have been linked to the subthalamic nucleus (STN), and therapeutic STN deep-brain stimulation (DBS) has been shown to interfere with this function. Here, we performed continuous as well as closed-loop DBS of the STN while Parkinson's disease patients performed a perceptual decision-making task. C...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.cub.2018.02.057

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
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National Institute of Health Research More from this funder
Parkinson Appeal UK More from this funder
Monument Trust More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Current Biology Journal website
Volume:
28
Issue:
8
Pages:
1169-1178.e6
Publication date:
2018-03-29
Acceptance date:
2018-02-21
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
Source identifiers:
832409
Keywords:
Pubs id:
pubs:832409
UUID:
uuid:6ab5e54a-d780-4b5e-89e8-92e59549884d
Local pid:
pubs:832409
Deposit date:
2018-04-04

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