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Journal article

l‐Dopa responsiveness is associated with distinctive connectivity patterns in advanced Parkinson's disease

Abstract:

BACKGROUND:Neuronal loss and dopamine depletion alter motor signal processing between cortical motor areas, basal ganglia, and the thalamus, resulting in the motor manifestations of Parkinson's disease. Dopamine replacement therapy can reverse these manifestations with varying degrees of improvement. METHODS:To evaluate functional connectivity in patients with advanced Parkinson's disease and changes in functional connectivity in relation to the degree of response to l-dopa, 19 patients with ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1002/mds.27017

Authors


More from this funder
Name:
Medical Research Council
Grant:
MR/M009106/1
More from this funder
Name:
Wellcome Trust
Grant:
104765/Z/14/Z
091593/Z/10/Z
Publisher:
Wiley
Journal:
Movement Disorders More from this journal
Volume:
32
Issue:
6
Pages:
874-883
Publication date:
2017-05-08
Acceptance date:
2017-03-03
DOI:
EISSN:
1531-8257
ISSN:
0885-3185
Pmid:
28597560
Language:
English
Keywords:
Pubs id:
pubs:718786
UUID:
uuid:6ab4b8e4-12a2-431c-b5a6-78918ffe1bad
Local pid:
pubs:718786
Source identifiers:
718786
Deposit date:
2019-03-11

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