Journal article
An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the HLA-DRB1gene
- Abstract:
-
Background: Multiple sclerosis (MS) is a complex trait in which genes in the MHC class II region exert the single strongest effect on genetic susceptibility. The principal MHC class II haplotype that increases MS risk in individuals of Northern European descent are those that bear HLA-DRB1*15. However, several other HLA-DRB1 alleles have been positively and negatively associated with MS and each of the main allelotypes is composed of many sub-allelotype...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- BioMed Central Publisher's website
- Journal:
- BMC Medical Genetics Journal website
- Volume:
- 10
- Article number:
- 10
- Publication date:
- 2009-02-04
- Acceptance date:
- 2009-02-04
- DOI:
- EISSN:
-
1471-2350
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:6ab154bb-f150-4ffe-924b-5f4a9397b664
- Local pid:
- pubs:34588
- Source identifiers:
-
34588
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Ramagopalan et al
- Copyright date:
- 2009
- Notes:
- © 2009 Ramagopalan et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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