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Changes in cardiac glycoside receptor sites, 86rubidium uptake and intracellular sodium concentrations in the erythrocytes of patients receiving digoxin during the early phases of treatment of cardiac failure in regular rhythm and of atrial fibrillation.

Abstract:

1 Measurements of the binding of 12-alpha-[3H]-digoxin to the membranes of intact erythrocytes, erythrocytic 86rubidium uptake and intraerythrocytic sodium concentrations have been made in the red cells of patients receiving digoxin in the short-term for atrial fibrillation or cardiac failure in regular rhythm. 2 During the first few days of treatment [3H]-digoxin binding and 86rubidium uptake fall and intraerythrocytic sodium concentrations rise. 3 Subsequently parallel fluctuations occur in...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-Seniors
Grahame-Smith, DG More by this author
Carver, JG More by this author
Journal:
British journal of clinical pharmacology
Volume:
8
Issue:
2
Pages:
125-134
Publication date:
1979-08-05
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
URN:
uuid:6aa947ba-caf1-4884-9051-c2b490afee4d
Source identifiers:
322122
Local pid:
pubs:322122

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