Conference item
The adenosine A2B receptor (ADORA2B) drives osteoclast-mediated bone resorption in hypoxia
- Abstract:
-
Osteoclast-mediated bone resorption is enhanced in the hypoxic microenvironment of diseases including rheumatoid arthritis and bone metastatic cancer. This increased resorption is driven by the hypoxia-inducible transcription factor, HIF. ADORA2b is a HIF-responsive gene that is upregulated in hypoxic osteoclasts. ADORA2b is only functional in hypoxia or inflammatory conditions, as only then are activating extracellular concentrations of adenosine achieved by hydrolysis of extracellular ATP. ...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Reviewed (other)
Actions
Authors
Bibliographic Details
- Publisher:
- Hylonome Publisher's website
- Host title:
- Bone Research Society Annual Meeting 2017
- Journal:
- Bone Research Society Annual Meeting 2017 Journal website
- Publication date:
- 2018-03-01
- Acceptance date:
- 2017-03-16
Item Description
- Pubs id:
-
pubs:687913
- UUID:
-
uuid:6aa9460d-7e41-4ebf-9222-232edebb12d4
- Local pid:
- pubs:687913
- Source identifiers:
-
687913
- Deposit date:
- 2017-04-05
Terms of use
- Copyright holder:
- Journal of Musculoskeletal and Neuronal Interactions
- Copyright date:
- 2018
- Notes:
- © Journal of Musculoskeletal and Neuronal Interactions. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record