A mathematical model for simultaneous spatio-temporal dynamics of calcium and inositol 1,4,5-trisphosphate in Madin-Darby canine kidney epithelial cells.

Journal article

The landmark paper by Hirose et al. (Hirose, K., Kadowaki, S., Tanabe, M., Takeshima, H., Iino, M., Science 284:1527-1530, 1999) presented experimental investigations to show that not only can calcium upregulate IP(3), but that it can also have an inhibitory effect on IP(3). In this paper, we present a preliminary model, which is consistent with these experiments. This model includes positive and negative feedback between calcium and IP(3) and is able to reproduce more precisely the data pres...

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Authors: Roose, T; Chapman, S; Maini, P

• Publication status: Published
• Journal: Bulletin of mathematical biology
• Volume: 68
• Issue: 8
• Pages: 2027-2051
• Publication date: 2006-11-01
• DOI: 10.1007/s11538-006-9064-1
• EISSN: 1522-9602
• ISSN: 0092-8240
• Language: English
• Keywords: Cell Line; Dogs; Signal Transduction; Models, Biological; Kidney; Adenosine Triphosphate; Epithelial Cells; Animals; Inositol 1,4,5-Trisphosphate; Calcium