- Abstract:
-
It is believed that free fatty acids contribute to the pathogenesis of type 2 diabetes in humans. We have recently shown that lipoapoptosis of human beta-cells is specifically induced by saturated fatty acids while unsaturated had no effect. In the present study we tested the effect of co-incubation of different saturated and unsaturated free fatty acids on lipoapoptosis in beta-cells. RIN1046-38 cells and isolated human beta-cells were incubated with combinations of saturated fatty acids (pa...
Expand abstract - Publisher copy:
- 10.1016/s0006-291x(02)02752-3
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- Journal:
- Biochemical and biophysical research communications
- Volume:
- 299
- Issue:
- 5
- Pages:
- 853-856
- Publication date:
- 2002-12-05
- DOI:
- EISSN:
-
1090-2104
- ISSN:
-
0006-291X
- URN:
-
uuid:6a9e9d48-6176-4b9b-841f-8139c0b91f8d
- Source identifiers:
-
260692
- Local pid:
- pubs:260692
- Copyright date:
- 2002
Journal article
Different role of saturated and unsaturated fatty acids in beta-cell apoptosis.
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