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Recruitment into stress granules prevents irreversible aggregation of FUS protein mislocalized to the cytoplasm.

Abstract:

Fused in sarcoma (FUS) belongs to the group of RNA-binding proteins implicated as underlying factors in amyotrophic lateral sclerosis (ALS) and certain other neurodegenerative diseases. Multiple FUS gene mutations have been linked to hereditary forms, and aggregation of FUS protein is believed to play an important role in pathogenesis of these diseases. In cultured cells, FUS variants with disease-associated amino acid substitutions or short deletions affecting nuclear localization signal (NL...

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Publisher copy:
10.4161/cc.26241
Journal:
Cell cycle (Georgetown, Tex.) More from this journal
Volume:
12
Issue:
19
Pages:
3194-3202
Publication date:
2013-10-01
DOI:
EISSN:
1551-4005
ISSN:
1538-4101
Language:
English
Keywords:
Pubs id:
pubs:492367
UUID:
uuid:6a9c6cfa-508d-45f1-813b-6463368a5fed
Local pid:
pubs:492367
Source identifiers:
492367
Deposit date:
2014-12-19

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