Journal article icon

Journal article

Matrix metalloproteinase-9 regulates tumor cell invasion through cleavage of protease nexin-1.

Abstract:

Matrix metalloproteinase-9 (MMP-9) expression is known to enhance the invasion and metastasis of tumor cells. In previous work based on a proteomic screen, we identified the serpin protease nexin-1 (PN-1) as a potential target of MMP-9. Here, we show that PN-1 is a substrate for MMP-9 and establish a link between PN-1 degradation by MMP-9 and regulation of invasion. PN-1 levels increased in prostate carcinoma cells after downregulation of MMP-9 and in tissues of MMP-9-deficient mice, consiste...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Expand authors...
Journal:
Cancer research
Volume:
70
Issue:
17
Pages:
6988-6998
Publication date:
2010-09-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:6a9c11d4-6edf-4083-8f6c-a4b6a1b1f14c
Source identifiers:
67494
Local pid:
pubs:67494

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP