Journal article
Matrix metalloproteinase-9 regulates tumor cell invasion through cleavage of protease nexin-1.
- Abstract:
-
Matrix metalloproteinase-9 (MMP-9) expression is known to enhance the invasion and metastasis of tumor cells. In previous work based on a proteomic screen, we identified the serpin protease nexin-1 (PN-1) as a potential target of MMP-9. Here, we show that PN-1 is a substrate for MMP-9 and establish a link between PN-1 degradation by MMP-9 and regulation of invasion. PN-1 levels increased in prostate carcinoma cells after downregulation of MMP-9 and in tissues of MMP-9-deficient mice, consiste...
Expand abstract
- Publication status:
- Published
Actions
Access Document
- Publisher copy:
- 10.1158/0008-5472.can-10-0242
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Bibliographic Details
- Journal:
- Cancer research
- Volume:
- 70
- Issue:
- 17
- Pages:
- 6988-6998
- Publication date:
- 2010-09-01
- DOI:
- EISSN:
-
1538-7445
- ISSN:
-
0008-5472
- Source identifiers:
-
67494
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:67494
- UUID:
-
uuid:6a9c11d4-6edf-4083-8f6c-a4b6a1b1f14c
- Local pid:
- pubs:67494
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2010
If you are the owner of this record, you can report an update to it here: Report update to this record