Journal article
Matrix metalloproteinase-9 regulates tumor cell invasion through cleavage of protease nexin-1.
- Abstract:
-
Matrix metalloproteinase-9 (MMP-9) expression is known to enhance the invasion and metastasis of tumor cells. In previous work based on a proteomic screen, we identified the serpin protease nexin-1 (PN-1) as a potential target of MMP-9. Here, we show that PN-1 is a substrate for MMP-9 and establish a link between PN-1 degradation by MMP-9 and regulation of invasion. PN-1 levels increased in prostate carcinoma cells after downregulation of MMP-9 and in tissues of MMP-9-deficient mice, consiste...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Cancer research
- Volume:
- 70
- Issue:
- 17
- Pages:
- 6988-6998
- Publication date:
- 2010-09-01
- DOI:
- EISSN:
-
1538-7445
- ISSN:
-
0008-5472
- Source identifiers:
-
67494
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:67494
- UUID:
-
uuid:6a9c11d4-6edf-4083-8f6c-a4b6a1b1f14c
- Local pid:
- pubs:67494
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2010
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