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Presentation by myoblasts of an epitope from endogenous acetylcholine receptor indicates a potential role in the spreading of the immune response.

Abstract:

It is generally considered that myoblasts are unable to prime naive T cell responses without help from professional antigen-presenting cells (APC). However, their ability to present endogenous antigens to previously primed T lymphocytes in the secondary phase of a T cell response has not been well studied. We show here that primary human myoblasts, when stimulated with IFNgamma to express class II MHC, can present an endogenous epitope, probably an acetylcholine receptor (AChR) peptide, to a ...

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Publication status:
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Authors


Corlett, L More by this author
Willcox, N More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Journal:
Journal of neuroimmunology
Volume:
115
Issue:
1-2
Pages:
127-134
Publication date:
2001-04-05
DOI:
EISSN:
1872-8421
ISSN:
0165-5728
URN:
uuid:6a97caba-cba7-422d-84af-cb859b063b45
Source identifiers:
241122
Local pid:
pubs:241122

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