- Abstract:
-
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32. We further found shared genetic variation with related vascular traits, including blood pressure, cardiac traits, and venous thromboembolism, at individual loci (n = 18), and using genetic risk scores and linkagedi...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
- Files:
-
-
(pdf, 779.4KB)
-
- Publisher copy:
- 10.1038/s41588-018-0058-3
-
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- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Genetics Journal website
- Volume:
- 50
- Pages:
- 524–537
- Publication date:
- 2018-03-12
- Acceptance date:
- 2018-01-08
- DOI:
- EISSN:
-
1546-1718
- ISSN:
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1061-4036
- Pubs id:
-
pubs:830305
- URN:
-
uri:6a8fb04f-efac-41b4-bed9-4cda00f7ed55
- UUID:
-
uuid:6a8fb04f-efac-41b4-bed9-4cda00f7ed55
- Local pid:
- pubs:830305
- Language:
- English
- Keywords:
- Copyright holder:
- Nature America Inc.
- Copyright date:
- 2018
- Notes:
- © 2018 Nature America Inc., part of Springer Nature. All rights reserved. This is the accepted manuscript version of the article. The final version is available online from Nature Publishing Group at: https://doi.org/10.1038/s41588-018-0058-3
Journal article
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
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