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Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Abstract:

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32. We further found shared genetic variation with related vascular traits, including blood pressure, cardiac traits, and venous thromboembolism, at individual loci (n = 18), and using genetic risk scores and linkagedi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/s41588-018-0058-3

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Department of Population Health, Clinical Trial Service Unit
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Oxford college:
St Johns College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
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Please see Supplementary Note on Journal website for full list of funders More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Genetics Journal website
Volume:
50
Pages:
524–537
Publication date:
2018-03-12
Acceptance date:
2018-01-08
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Pubs id:
pubs:830305
URN:
uri:6a8fb04f-efac-41b4-bed9-4cda00f7ed55
UUID:
uuid:6a8fb04f-efac-41b4-bed9-4cda00f7ed55
Local pid:
pubs:830305

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