Structural and functional analysis of the human CD45 gene (PTPRC) upstream region: evidence for a functional promoter within the first intron of the gene.

Journal article

Expression of the leucocyte common antigen (CD45) in mammals is restricted to the nucleated lineages of haematopoietic cells. It appears in early progenitors in the bone marrow and is expressed at the surface of these cells throughout their differentiation. However, at least in T cells, the pattern of expression switches between different isoforms during the successive stages of differentiation in the thymus and after activation in the periphery. In order to understand the mechanisms controll...

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Authors: Timón, M; Beverley, P

• Journal: Immunology
• Volume: 102
• Issue: 2
• Pages: 180-189
• Publication date: 2001-02-01
• DOI: 10.1046/j.1365-2567.2001.01177.x
• EISSN: 1365-2567
• ISSN: 0019-2805
• Language: English
• Keywords: Humans; Transcription, Genetic; Molecular Sequence Data; Mice; Promoter Regions, Genetic; Conserved Sequence; Animals; Chickens; Antigens, CD45; Tumor Cells, Cultured; Base Sequence; Gene Expression Regulation; Introns; Genes, Reporter