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Structural and functional analysis of the human CD45 gene (PTPRC) upstream region: evidence for a functional promoter within the first intron of the gene.

Abstract:

Expression of the leucocyte common antigen (CD45) in mammals is restricted to the nucleated lineages of haematopoietic cells. It appears in early progenitors in the bone marrow and is expressed at the surface of these cells throughout their differentiation. However, at least in T cells, the pattern of expression switches between different isoforms during the successive stages of differentiation in the thymus and after activation in the periphery. In order to understand the mechanisms controll...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
Immunology More from this journal
Volume:
102
Issue:
2
Pages:
180-189
Publication date:
2001-02-01
DOI:
EISSN:
1365-2567
ISSN:
0019-2805
Language:
English
Keywords:
Pubs id:
pubs:31846
UUID:
uuid:6a8f3e3e-cda2-4832-9147-80e79c979d88
Local pid:
pubs:31846
Source identifiers:
31846
Deposit date:
2012-12-20

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