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Journal article

Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo

Abstract:

The genome is organized via CTCF-cohesin-binding sites, which partition chromosomes into 1-5 megabase (Mb) topologically associated domains (TADs), and further into smaller sub-domains (sub-TADs). Here we examined in vivo an ∼80 kb sub-TAD, containing the mouse α-globin gene cluster, lying within a ∼1 Mb TAD. We find that the sub-TAD is flanked by predominantly convergent CTCF-cohesin sites that are ubiquitously bound by CTCF but only interact during erythropoiesis, defining a self-interactin...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/ncb3573

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Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
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Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
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Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
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Funding agency for:
Hanssen, LLP
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Funding agency for:
Oudelaar, AM
Publisher:
Springer Nature Publisher's website
Journal:
Nature Cell Biology Journal website
Volume:
19
Issue:
8
Pages:
952–961
Publication date:
2017-07-24
DOI:
EISSN:
1465-7392
ISSN:
1476-4679
Pubs id:
pubs:709225
URN:
uri:6a8e9183-8e9e-410a-8685-3fe6f110801c
UUID:
uuid:6a8e9183-8e9e-410a-8685-3fe6f110801c
Local pid:
pubs:709225
Language:
English
Keywords:

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