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Journal article : Review

E2F1: Cause and consequence of DNA replication stress

Abstract:

In mammalian cells, cell cycle entry occurs in response to the correct stimuli and is promoted by the transcriptional activity of E2F family members. E2F proteins regulate the transcription of S phase cyclins and genes required for DNA replication, DNA repair, and apoptosis. The activity of E2F1, the archetypal and most heavily studied E2F family member, is tightly controlled by the DNA damage checkpoints to modulate cell cycle progression and initiate programmed cell death, when required. Al...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fmolb.2020.599332

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Name:
Brain Tumour Charity
Grant:
GN-000559
Publisher:
Frontiers Media
Journal:
Frontiers in Molecular Biosciences More from this journal
Volume:
7
Article number:
599332
Publication date:
2021-02-16
DOI:
EISSN:
2296-889X
Language:
English
Keywords:
Subtype:
Review
Pubs id:
1174195
Local pid:
pubs:1174195
Deposit date:
2021-05-05

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