Alpha-flupenthixol-induced hyperactivity by chronic dosing in rats.

Journal article

Socially reared and isolation-reared rats treated chronically since weaning with alpha-flupenthixol showed elevated levels of spontaneous locomotor activity compared with control treated rats. However, chronic apomorphine treatment had no effect on spontaneous locomotor activity. Chronic alpha-flupenthixol treatment enhanced stereotyped behaviour after 1.5 mg/kg d-amphetamine or 0.5 mg/kg apomorphine in the socially reared condition. 'Spontaneous stereotypies' were also observed in the chroni...

Expand abstract

Authors: Sahakian, B; Robbins, T; Iversen, S

• Publication status: Published
• Journal: European journal of pharmacology
• Volume: 37
• Issue: 1
• Pages: 169-178
• Publication date: 1976-05-01
• DOI: 10.1016/0014-2999(76)90019-4
• EISSN: 1879-0712
• ISSN: 0014-2999
• Language: English
• Keywords: Stimulation, Chemical; Humans; Thioxanthenes; Social Environment; Social Isolation; Animals; Dextroamphetamine; Female; Body Weight; Motor Activity; Flupenthixol; Apomorphine; Stereotyped Behavior; Rats