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Thesis

Development of models and methods to assess the efficacy of anti-cancer drugs targeted to the mitochondria

Abstract:

Background: Malignant transformation of cells is typically characterised by aerobic glycolysis, resulting in supressed mitochondrial function, a state that helps resistance to apoptosis. This characteristic has been widely accepted as a hallmark of cancer and has been shown to be of critical importance in tumour development. The bioenergetic differences between normal and malignant cells are being exploited to identify potential cancer specific therapeutics. Improved in-vi...

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Institution:
University of Oxford
Division:
MSD
Department:
Women's and Reproductive Health
Research group:
Morton Group
Oxford college:
Mansfield College
Role:
Author

Contributors

Role:
Supervisor
More from this funder
Name:
William's Fund
Funding agency for:
Potter, M
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:6a847ae9-3664-437e-ad26-c1ae3d94f7c0
Local pid:
ora:11368
Deposit date:
2015-05-06

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