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Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria.

Abstract:

BACKGROUND: Our study examined the relative contributions of host, pharmacokinetic, and parasitological factors in determining the therapeutic response to artemether-lumefantrine (AL). METHODS: On the northwest border of Thailand, patients with uncomplicated Plasmodium falciparum malaria were enrolled in prospective studies of AL treatment (4- or 6-dose regimens) and followed up for 42 days. Plasma lumefantrine concentrations were measured by high performance liquid chromatography; malaria pa...

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Publication status:
Published

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Publisher copy:
10.1086/503423

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Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America More from this journal
Volume:
42
Issue:
11
Pages:
1570-1577
Publication date:
2006-06-01
DOI:
EISSN:
1537-6591
ISSN:
1058-4838

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