The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease.

Journal article

Mutations in the adenomatous polyposis coli (APC) gene are the basis of familial adenomatous polyposis and the majority of sporadic colorectal cancer. APC is expressed in a wide variety of tissues, interacts with the cytoskeleton, is involved in regulating levels of beta-catenin and, most recently, has been shown to bind DNA, suggesting that it may possess a nuclear role. The mutation spectrum implicated in tumorigenesis and its correlation with disease phenotype is well characterized and has...

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Authors: Sieber, O; Tomlinson, I; Lamlum, H

• Publication status: Published
• Journal: Molecular medicine today
• Volume: 6
• Issue: 12
• Pages: 462-469
• Publication date: 2000-12-01
• DOI: 10.1016/s1357-4310(00)01828-1
• ISSN: 1357-4310
• Language: English
• Keywords: Mutation; Adenomatous Polyposis Coli; Adenomatous Polyposis Coli Protein; Humans; Cytoskeletal Proteins; Colorectal Neoplasms; Genes, APC