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Journal article

Elucidating the function of non catalytic domains of collagenases and aggrecanases.

Abstract:

Metalloproteinases that degrade extracellular matrix molecules play important roles in development and progression of various diseases. Among them, collagenases are unique as they have an ability to degrade triple helical interstitial collagens into 3/4 and 1/4 fragments, a crucial step for collagenolysis in the tissue. Collagenases, consisting of a catalytic domain and a hemopexin domain, requires both domains for collagenolysis. The enzymes unwind triple helical collagen before they hydroly...

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Publication status:
Published

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Publisher copy:
10.1080/03008200802151698

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Connective tissue research More from this journal
Volume:
49
Issue:
3
Pages:
169-174
Publication date:
2008-01-01
DOI:
EISSN:
1607-8438
ISSN:
0300-8207
Language:
English
Keywords:
Pubs id:
pubs:226661
UUID:
uuid:6a7bebd6-222c-4d44-bf28-083f2a75baf3
Local pid:
pubs:226661
Source identifiers:
226661
Deposit date:
2012-12-19

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