Journal article
The haptoglobin 2-2 genotype is associated with a reduced incidence of Plasmodium falciparum malaria in children on the coast of Kenya.
- Abstract:
-
BACKGROUND: Haptoglobin (Hp) genotype determines the efficiency of hemoglobin clearance after malaria-induced hemolysis and alters antioxidant and immune functions. The Hp2 allele is thought to have spread under strong selection pressure, but it is unclear whether this is due to protection from malaria or other diseases. METHODS: We monitored the incidence of febrile malaria and other childhood illnesses with regard to Hp genotype in a prospective cohort of 312 Kenyan children during 558.3 ch...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1086/511868
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Authors
Funding
Wellcome Trust
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European Union
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Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Clinical Infectious Diseases Journal website
- Volume:
- 44
- Issue:
- 6
- Pages:
- 802-809
- Publication date:
- 2007-01-01
- DOI:
- EISSN:
-
1537-6591
- ISSN:
-
1058-4838
- URN:
-
uuid:6a7bb9e2-ccea-4665-a211-959ef9f4f83f
- Source identifiers:
-
324334
- Local pid:
- pubs:324334
Terms of use
- Copyright holder:
- Infectious Diseases Society of America
- Copyright date:
- 2007
- Notes:
- Copyright © 2007 by the Infectious Diseases Society of America
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