Journal article icon

Journal article

The haptoglobin 2-2 genotype is associated with a reduced incidence of Plasmodium falciparum malaria in children on the coast of Kenya.

Abstract:

BACKGROUND: Haptoglobin (Hp) genotype determines the efficiency of hemoglobin clearance after malaria-induced hemolysis and alters antioxidant and immune functions. The Hp2 allele is thought to have spread under strong selection pressure, but it is unclear whether this is due to protection from malaria or other diseases. METHODS: We monitored the incidence of febrile malaria and other childhood illnesses with regard to Hp genotype in a prospective cohort of 312 Kenyan children during 558.3 ch...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1086/511868

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Paediatrics
Mwangi, TW More by this author
Macharia, AW More by this author
Expand authors...
Wellcome Trust More from this funder
European Union More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Clinical Infectious Diseases Journal website
Volume:
44
Issue:
6
Pages:
802-809
Publication date:
2007
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
URN:
uuid:6a7bb9e2-ccea-4665-a211-959ef9f4f83f
Source identifiers:
324334
Local pid:
pubs:324334

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP