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The therapeutic potential of CXC chemokine blockade in acute inflammation in the brain.

Abstract:

Mammalian neurones of the central nervous system (CNS) are terminally differentiated, and there is little endogenous capacity of the CNS to repair itself. Peripheral tissue injury, disease or infection results in a stereotypical inflammatory response to protect the host from pathogens and to promote tissue repair. However, collateral or 'bystander' damage is characteristic of any inflammatory response. Thus, it is apparent that the CNS has evolved mechanisms to regulate tightly the acute infl...

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Publisher copy:
10.1517/13543784.8.4.363

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Publisher:
Ashley Publications Ltd
Journal:
Expert opinion on investigational drugs
Volume:
8
Issue:
4
Pages:
363-371
Publication date:
1999-04-05
DOI:
EISSN:
1744-7658
ISSN:
1354-3784
URN:
uuid:6a782fdc-9f79-4815-9f5d-3275e57c6a35
Source identifiers:
383074
Local pid:
pubs:383074

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