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Axonal loss in multiple sclerosis: a pathological survey of the corticospinal and sensory tracts.

Abstract:

Clinical, imaging, and pathological studies in multiple sclerosis have generally emphasized the relative preservation of axons in comparison with myelin. Recent evidence, however, demonstrates that axonal loss is also significant, affects long tracts such as the corticospinal and sensory tracts and relates closely to functional disability. Accordingly, the distribution and extent of this axonal loss is the focus of the current investigation. Post-mortem material of 55 multiple sclerosis patie...

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Publication status:
Published

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Publisher copy:
10.1093/brain/awh118

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, WTC Human Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
Journal:
Brain : a journal of neurology
Volume:
127
Issue:
Pt 5
Pages:
1009-1018
Publication date:
2004-05-05
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
URN:
uuid:6a73aa59-1f24-461c-9d9e-1c9eb5595eb1
Source identifiers:
32664
Local pid:
pubs:32664

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