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Journal article

The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis.

Abstract:

Of 11 genes involved in nonspecific X-linked mental retardation (MRX), three encode regulators or effectors of the Rho GTPases, suggesting an important role for Rho signaling in cognitive function. It remains unknown, however, how mutations in Rho-linked genes lead to MRX. Here we report that oligophrenin-1, a Rho-GTPase activating protein that is absent in a family affected with MRX, is required for dendritic spine morphogenesis. Using RNA interference and antisense RNA approaches, we show t...

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Publication status:
Published

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Publisher copy:
10.1038/nn1210

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
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Journal:
Nature neuroscience
Volume:
7
Issue:
4
Pages:
364-372
Publication date:
2004-04-05
DOI:
EISSN:
1546-1726
ISSN:
1097-6256
URN:
uuid:6a6a48c9-744b-440b-b9a2-6b39734c3420
Source identifiers:
185152
Local pid:
pubs:185152

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