DNA polymorphism as an origin of adenine-thymine tract length-dependent threading intercalation rate.

Journal article

Binuclear ruthenium complexes that bind DNA by threading intercalation have recently been found to exhibit an exceptional kinetic selectivity for long polymeric adenine-thymine (AT) DNA. A series of oligonucleotide hairpin duplexes containing a central tract of 6-44 alternating AT base pairs have here been used to investigate the nature of the recognition mechanism. We find that, above a threshold AT tract length corresponding to one helix turn of B-DNA, a dramatic increase in threading inter...

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Authors: Nordell, P; Westerlund, F; Reymer, A; El-Sagheer, A; Brown, T

• Publication status: Published
• Journal: Journal of the American Chemical Society
• Volume: 130
• Issue: 44
• Pages: 14651-14658
• Publication date: 2008-11-01
• DOI: 10.1021/ja804427q
• EISSN: 1520-5126
• ISSN: 0002-7863
• Language: English
• Keywords: Nucleic Acid Conformation; Kinetics; Ruthenium; Luminescent Measurements; DNA; Adenine; Temperature; Crystallization; Thymine; Base Pairing; Organometallic Compounds; Intercalating Agents; Oligonucleotides