Journal article
The spinal muscular atrophy protein SMN affects Drosophila germline nuclear organization through the U body-P body pathway.
- Abstract:
-
Survival motor neuron protein (SMN) is the determining factor for the human neurodegenerative disease spinal muscular atrophy (SMA). SMN is critical for small nuclear ribonucleoprotein (snRNP) assembly. Using Drosophila oogenesis as a model system, we show that mutations in smn cause abnormal nuclear organization in nurse cells and oocytes. Germline and mitotic clonal analysis reveals that both nurse cells and oocytes require SMN to maintain normal organization of nuclear compartments includi...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.ydbio.2009.05.553
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Authors
Bibliographic Details
- Journal:
- Developmental biology
- Volume:
- 332
- Issue:
- 1
- Pages:
- 142-155
- Publication date:
- 2009-08-01
- DOI:
- EISSN:
-
1095-564X
- ISSN:
-
0012-1606
- Source identifiers:
-
115549
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:115549
- UUID:
-
uuid:6a5fb841-9bd8-4fb4-8e05-1b5864f7290b
- Local pid:
- pubs:115549
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2009
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