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The spinal muscular atrophy protein SMN affects Drosophila germline nuclear organization through the U body-P body pathway.

Abstract:

Survival motor neuron protein (SMN) is the determining factor for the human neurodegenerative disease spinal muscular atrophy (SMA). SMN is critical for small nuclear ribonucleoprotein (snRNP) assembly. Using Drosophila oogenesis as a model system, we show that mutations in smn cause abnormal nuclear organization in nurse cells and oocytes. Germline and mitotic clonal analysis reveals that both nurse cells and oocytes require SMN to maintain normal organization of nuclear compartments includi...

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Publication status:
Published

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Publisher copy:
10.1016/j.ydbio.2009.05.553

Authors


Davies, SE More by this author
Journal:
Developmental biology
Volume:
332
Issue:
1
Pages:
142-155
Publication date:
2009-08-05
DOI:
EISSN:
1095-564X
ISSN:
0012-1606
URN:
uuid:6a5fb841-9bd8-4fb4-8e05-1b5864f7290b
Source identifiers:
115549
Local pid:
pubs:115549

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