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Multiple Ets factors and interferon regulatory factor-4 modulate CD68 expression in a cell type-specific manner.

Abstract:

CD68 is a transmembrane glycoprotein expressed in all cells of the mononuclear phagocyte lineage including monocytes and tissue resident macrophages. Deletion analysis of the 5'-flanking sequences of the gene demonstrated that the proximal -150-bp sequence of the CD68 promoter exhibits high level promoter activity in macrophages. Mutations that abolish Ets factor binding at positions -106 and -89 reduce promoter activity in macrophages to 12 and 30%, respectively. Band shift experiments show ...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m212150200

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
El-Shanawany, T More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School, BHF Centre of Research Excellence
Journal:
The Journal of biological chemistry
Volume:
278
Issue:
24
Pages:
21909-21919
Publication date:
2003-06-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:6a5f696f-41a5-466b-8e15-57f01b4219b4
Source identifiers:
18570
Local pid:
pubs:18570

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