- Abstract:
-
CD68 is a transmembrane glycoprotein expressed in all cells of the mononuclear phagocyte lineage including monocytes and tissue resident macrophages. Deletion analysis of the 5'-flanking sequences of the gene demonstrated that the proximal -150-bp sequence of the CD68 promoter exhibits high level promoter activity in macrophages. Mutations that abolish Ets factor binding at positions -106 and -89 reduce promoter activity in macrophages to 12 and 30%, respectively. Band shift experiments show ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1074/jbc.m212150200
-
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- Journal:
- The Journal of biological chemistry
- Volume:
- 278
- Issue:
- 24
- Pages:
- 21909-21919
- Publication date:
- 2003-06-05
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- URN:
-
uuid:6a5f696f-41a5-466b-8e15-57f01b4219b4
- Source identifiers:
-
18570
- Local pid:
- pubs:18570
- Language:
- English
- Keywords:
- Copyright date:
- 2003
Journal article
Multiple Ets factors and interferon regulatory factor-4 modulate CD68 expression in a cell type-specific manner.
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