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Recombinant vaccinia viruses for the characterization of Plasmodium falciparum-specific cytotoxic T lymphocytes: recognition of processed antigen despite limited re-stimulation efficacy.

Abstract:

Cytotoxic T lymphocytes (CTL) have been implicated in immunity to Plasmodium falciparum infection and disease. We have previously described the use of peptides to define malaria-specific CTL epitopes. To determine whether these peptide epitopes are processed intracellularly from the whole antigen we have developed recombinant vaccinia viruses (rVV) expressing three malaria antigens: thrombospondin-related adhesive protein (TRAP), Pfs16 and the C-terminal half of liver-stage antigen (LSA)-1. T...

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Publication status:
Published

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Publisher copy:
10.1093/intimm/9.5.731

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
Journal:
International immunology More from this journal
Volume:
9
Issue:
5
Pages:
731-737
Publication date:
1997-05-01
DOI:
EISSN:
1460-2377
ISSN:
0953-8178
Language:
English
Keywords:
Pubs id:
pubs:36055
UUID:
uuid:6a5f5a4e-2a70-41cf-956b-d60d7ca6db87
Local pid:
pubs:36055
Source identifiers:
36055
Deposit date:
2012-12-19

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