Convergence of cortical and thalamic input to direct and indirect pathway medium spiny neurons in the striatum.

Journal article

The major afferent innervation of the basal ganglia is derived from the cortex and the thalamus. These excitatory inputs mainly target the striatum where they innervate the principal type of striatal neuron, the medium-sized spiny neurons (MSNs), and are critical in the expression of basal ganglia function. The aim of this work was to test directly whether corticostriatal and thalamostriatal terminals make convergent synaptic contact with individual direct and indirect pathway MSNs. Individua...

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Authors: Huerta-Ocampo, I; Mena-Segovia, J; Bolam, J

• Publication status: Published
• Journal: Brain structure and function
• Volume: 219
• Issue: 5
• Pages: 1787-1800
• Publication date: 2014-09-01
• DOI: 10.1007/s00429-013-0601-z
• EISSN: 1863-2661
• ISSN: 1863-2653
• Language: English
• Keywords: Synapses; Thalamostriatal; Basal ganglia; Corticostriatal; Neostriatum