8-OH-DPAT elicits feeding and not chewing: evidence from liquid diet studies and a diet choice test.

Journal article

There have been recent claims that the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) elicits chewing and eating of solid but not liquid foods. Therefore, the effects of 8-OH-DPAT and another 5-HT1A agonist gepirone on the consumption of a liquid chow diet, by free feeding male rats, were examined. Both drugs produced a dose-dependent increase in the consumption of liquid diet during a 2 h test. The doses of 8-OH-DPAT and gepirone which increased liquid diet intake in this ...

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Authors: Dourish, C; Clark, M; Iversen, S

• Publication status: Published
• Journal: Psychopharmacology
• Volume: 95
• Issue: 2
• Pages: 185-188
• Publication date: 1988-01-01
• DOI: 10.1007/bf00174507
• EISSN: 1432-2072
• ISSN: 0033-3158
• Language: English
• Keywords: Dose-Response Relationship, Drug; Food, Formulated; Animals; 8-Hydroxy-2-(di-n-propylamino)tetralin; Rats; Tetrahydronaphthalenes; Male; Rats, Inbred Strains; Diet; Feeding Behavior; Choice Behavior; Naphthalenes