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Journal article

Enhancing blood-stage malaria subunit vaccine immunogenicity in rhesus macaques by combining adenovirus, poxvirus, and protein-in-adjuvant vaccines.

Abstract:

Protein-in-adjuvant formulations and viral-vectored vaccines encoding blood-stage malaria Ags have shown efficacy in rodent malaria models and in vitro assays against Plasmodium falciparum. Abs and CD4(+) T cell responses are associated with protective efficacy against blood-stage malaria, whereas CD8(+) T cells against some classical blood-stage Ags can also have a protective effect against liver-stage parasites. No subunit vaccine strategy alone has generated demonstrable high-level efficac...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.1001760

Authors


Draper, SJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Spencer, AJ More by this author
Remarque, EJ More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
185
Issue:
12
Pages:
7583-7595
Publication date:
2010-12-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:6a5d0616-759e-4547-96f8-64adf34092df
Source identifiers:
97280
Local pid:
pubs:97280

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