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Gene-environment interaction in determining plasma lipids and dietary response: The effect of common mutations in the gene for lipoprotein lipase (D9N and N291S)

Abstract:

In understanding the genetics of polygenic disorders, the modifying effects of the different environmental factors experienced by individuals are particularly important. We have detected such an interaction between environmental modulation of the effect of two mutations in the lipoprotein lipase gene which alter amino acids (D9N and N291S) to result in a moderate reduction in the lipoprotein lipase activity and mass secreted from COS cells in transient expression assays. Each mutation occurs ...

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Publication status:
Published

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Journal:
NUTRITION, GENETICS, AND HEART DISEASE
Volume:
6
Pages:
279-295
Publication date:
1996-01-01
Event title:
Conference on Nutrition, Genetics, and Heart Disease
Source identifiers:
19658
ISBN:
0807120510
Pubs id:
pubs:19658
UUID:
uuid:6a5a5683-8317-4d4f-8247-38add856bb44
Local pid:
pubs:19658
Deposit date:
2012-12-19

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