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Pharmacological validation of a semi-automated in vitro hippocampal brain slice assay for assessment of seizure liability.

Abstract:

INTRODUCTION: Drug-induced seizures are a serious, life-threatening adverse drug reaction (ADR) that can result in the failure of drugs to be licensed for clinical use or withdrawn from the market. Seizure liability of potential drugs is traditionally assessed using animal models run during the later phases of the drug discovery process. Given the low throughput, high animal usage and high compound requirement associated with these assays, it would be advantageous to identify higher throughpu...

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Publisher copy:
10.1016/j.vascn.2007.04.008

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Journal:
Journal of pharmacological and toxicological methods
Volume:
56
Issue:
2
Pages:
223-233
Publication date:
2007-01-01
DOI:
EISSN:
1873-488X
ISSN:
1056-8719
URN:
uuid:6a55ef07-ebb4-40f8-a5eb-7a616eb7d5c3
Source identifiers:
344116
Local pid:
pubs:344116

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