Journal article
NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress
- Abstract:
-
Transport of dietary cholesterol from endocytic organelles to the endoplasmic reticulum (ER) is essential for cholesterol homoeostasis, but the mechanism and regulation of this transport remains poorly defined. Membrane contact sites (MCS), microdomains of close membrane apposition, are gaining attention as important platforms for non-vesicular, inter-organellar communication. Here we investigate the impact of ER-endocytic organelle MCS on cholesterol transport. We report a role for Niemann-P...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature communications
- Volume:
- 10
- Article number:
- 4276
- Publication date:
- 2019-09-19
- Acceptance date:
- 2019-08-19
- DOI:
- EISSN:
-
2041-1723
- Pmid:
-
31537798
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1055365
- UUID:
-
uuid:6a4e5205-d5a6-45cd-95d4-133ca4127285
- Local pid:
- pubs:1055365
- Source identifiers:
-
1055365
- Deposit date:
- 2019-11-12
Terms of use
- Copyright date:
- 2019
- Notes:
- Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
- Licence:
- CC Attribution (CC BY)
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