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NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress

Abstract:

Transport of dietary cholesterol from endocytic organelles to the endoplasmic reticulum (ER) is essential for cholesterol homoeostasis, but the mechanism and regulation of this transport remains poorly defined. Membrane contact sites (MCS), microdomains of close membrane apposition, are gaining attention as important platforms for non-vesicular, inter-organellar communication. Here we investigate the impact of ER-endocytic organelle MCS on cholesterol transport. We report a role for Niemann-P...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-019-12152-2

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Role:
Author
ORCID:
0000-0002-8428-720X
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Role:
Author
ORCID:
0000-0001-9344-7714
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Role:
Author
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Name:
European Commission
Grant:
289278
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Name:
Wellcome Trust
Grant:
202834/Z/16/Z
Publisher:
Springer Nature
Journal:
Nature communications More from this journal
Volume:
10
Article number:
4276
Publication date:
2019-09-19
Acceptance date:
2019-08-19
DOI:
EISSN:
2041-1723
Pmid:
31537798
Language:
English
Keywords:
Pubs id:
pubs:1055365
UUID:
uuid:6a4e5205-d5a6-45cd-95d4-133ca4127285
Local pid:
pubs:1055365
Source identifiers:
1055365
Deposit date:
2019-11-12

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