Journal article
Myofibrillar Ca(2+) sensitivity is uncoupled from troponin I phosphorylation in hypertrophic obstructive cardiomyopathy due to abnormal troponin T.
- Abstract:
-
AIMS: We studied the relationship between myofilament Ca(2+) sensitivity and troponin I (TnI) phosphorylation by protein kinase A at serines 22/23 in human heart troponin isolated from donor hearts and from myectomy samples from patients with hypertrophic obstructive cardiomyopathy (HOCM). METHODS AND RESULTS: We used a quantitative in vitro motility assay. With donor heart troponin, Ca(2+) sensitivity is two- to three-fold higher when TnI is unphosphorylated. In the myectomy samples from pat...
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- Publication status:
- Published
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- Publisher copy:
- 10.1093/cvr/cvs322
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Authors
Bibliographic Details
- Journal:
- Cardiovascular research
- Volume:
- 97
- Issue:
- 3
- Pages:
- 500-508
- Publication date:
- 2013-03-01
- DOI:
- EISSN:
-
1755-3245
- ISSN:
-
0008-6363
- Source identifiers:
-
356220
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:356220
- UUID:
-
uuid:6a4c5515-82ba-4813-98d8-1c82b19966d8
- Local pid:
- pubs:356220
- Deposit date:
- 2013-11-17
Terms of use
- Copyright date:
- 2013
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