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111In-labeled EGF is selectively radiotoxic to human breast cancer cells overexpressing EGFR.

Abstract:

Our objective was to determine whether the internalization and nuclear translocation of human epidermal growth factor (hEGF) after binding to its cell surface receptor (EGFR) could be exploited to deliver the Auger electron emitter 111In into EGFR-positive breast cancer cells for targeted radiotherapy. METHODS: hEGF was derivatized with diethylenetriamine pentaacetic acid (DTPA) and radiolabeled with 111In-acetate. The internalization of 111In-DTPA-hEGF by MDA-MB-468 breast cancer cells (1.3x...

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Journal:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine More from this journal
Volume:
41
Issue:
3
Pages:
429-438
Publication date:
2000-03-01
EISSN:
1535-5667
ISSN:
0161-5505
Language:
English
Keywords:
Pubs id:
pubs:315092
UUID:
uuid:6a480a25-442b-4987-b6ea-3d2cdec31cbf
Local pid:
pubs:315092
Source identifiers:
315092
Deposit date:
2012-12-19

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