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The growth hormone releasing hormone (GHRH) response to a mixed meal is blunted in young adults with insulin-dependent diabetes mellitus whereas the somatostatin response is normal.

Abstract:

Following a standard mixed meal, plasma concentrations of growth hormone releasing hormone (GHRH), somatostatin (SMS) and growth hormone (GH) were measured every 30 min for 300 min in six young adults with type I insulin-dependent diabetes mellitus (IDDM) and five normal controls. Mean blood glucose concentrations were higher and mean free insulin levels lower in the diabetics compared with controls both in fasting specimens and at all times following the mixed meal. Basal concentrations (mea...

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Journal:
Clinical endocrinology More from this journal
Volume:
32
Issue:
2
Pages:
177-183
Publication date:
1990-02-01
DOI:
EISSN:
1365-2265
ISSN:
0300-0664
Language:
English
Keywords:
Pubs id:
pubs:6264
UUID:
uuid:6a4143c4-6c4c-4803-88b3-8f6a986a731b
Local pid:
pubs:6264
Source identifiers:
6264
Deposit date:
2012-12-19

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