Epidermal growth factor receptor and human epidermal growth factor receptor 2 gene polymorphisms in endometrial cancer in a Japanese population.

Journal article

Endometrial cancer is associated with both EGFR and HER2 receptor activation. The EGFR and HER2 genes could be disease susceptibility candidate genes for this cancer. This study was conducted to investigate a possible association between EGFR and HER2 gene polymorphisms and endometrial cancer and the influence of these polymorphisms on the clinical outcome of endometrial cancer patients in a Japanese population. The authors compare the genotype distributions and allele frequencies of the EGFR...

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Authors: Kitao, K; Yoshida, S; Kennedy, S; Takemura, N; Sugimoto, M

• Publication status: Published
• Journal: Reproductive sciences (Thousand Oaks, Calif.)
• Volume: 14
• Issue: 4
• Pages: 349-357
• Publication date: 2007-05-01
• DOI: 10.1177/1933719107303383
• EISSN: 1933-7205
• ISSN: 1933-7191
• Language: English
• Keywords: Receptor, Epidermal Growth Factor; Humans; Neoplasm Staging; Reference Values; Adult; Polymorphism, Genetic; Female; Asian Continental Ancestry Group; Polymorphism, Single Nucleotide; Guanine; Endometrial Neoplasms; Receptor, erbB-2; Genes, erbB-2; Middle Aged; Japan; Adenine