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Journal article

Glycosylation and lipids working in concert direct CD2 ectodomain orientation and presentation.

Abstract:

Proteins embedded in the plasma membrane mediate interactions with the cell environment and play decisive roles in many signaling events. For cell-cell recognition molecules it is highly likely that their structures and behavior have been optimized in ways that overcome the limitations of membrane tethering. In particular, the ligand binding regions of these proteins likely need to be maximally exposed. Here we show by means of atomistic simulations of membrane-bound CD2, a small cell adhesio...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acs.jpclett.6b02824

Authors


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Funding agency for:
Eggeling, C
Grant:
MR/K01577X/1
More from this funder
Funding agency for:
Eggeling, C
Grant:
MR/K01577X/1
More from this funder
Funding agency for:
Eggeling, C
Grant:
MR/K01577X/1
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Funding agency for:
Davis, S
Grant:
MR/K01577X/1
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Publisher:
American Chemical Society Publisher's website
Journal:
Journal of Physical Chemistry Letters Journal website
Volume:
8
Issue:
5
Pages:
1060-1066
Publication date:
2017-02-01
Acceptance date:
2017-02-13
DOI:
EISSN:
1948-7185
Source identifiers:
679962
Language:
English
Keywords:
Pubs id:
pubs:679962
UUID:
uuid:6a3492bc-d441-4ae6-88f0-5e27330eb0e4
Local pid:
pubs:679962
Deposit date:
2017-03-18

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