Journal article
Glycosylation and lipids working in concert direct CD2 ectodomain orientation and presentation.
- Abstract:
-
Proteins embedded in the plasma membrane mediate interactions with the cell environment and play decisive roles in many signaling events. For cell-cell recognition molecules it is highly likely that their structures and behavior have been optimized in ways that overcome the limitations of membrane tethering. In particular, the ligand binding regions of these proteins likely need to be maximally exposed. Here we show by means of atomistic simulations of membrane-bound CD2, a small cell adhesio...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Version of record, pdf, 2.9MB)
-
- Publisher copy:
- 10.1021/acs.jpclett.6b02824
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
+ Medical Research Council
More from this funder
Funding agency for:
Eggeling, C
Grant:
MR/K01577X/1
+ Biotechnology and Biological Sciences Research Council
More from this funder
Funding agency for:
Eggeling, C
Grant:
MR/K01577X/1
+ Engineering and Physical Sciences Research Council
More from this funder
Funding agency for:
Eggeling, C
Grant:
MR/K01577X/1
+ Biotechnology and Biological Sciences Research Council
More from this funder
Funding agency for:
Davis, S
Grant:
MR/K01577X/1
Expand funders...
Bibliographic Details
- Publisher:
- American Chemical Society Publisher's website
- Journal:
- Journal of Physical Chemistry Letters Journal website
- Volume:
- 8
- Issue:
- 5
- Pages:
- 1060-1066
- Publication date:
- 2017-02-01
- Acceptance date:
- 2017-02-13
- DOI:
- EISSN:
-
1948-7185
- Source identifiers:
-
679962
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:679962
- UUID:
-
uuid:6a3492bc-d441-4ae6-88f0-5e27330eb0e4
- Local pid:
- pubs:679962
- Deposit date:
- 2017-03-18
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2017
- Notes:
- © 2017 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record