Journal article icon

Journal article

Glycosylation and lipids working in concert direct CD2 ectodomain orientation and presentation.

Abstract:

Proteins embedded in the plasma membrane mediate interactions with the cell environment and play decisive roles in many signaling events. For cell-cell recognition molecules it is highly likely that their structures and behavior have been optimized in ways that overcome the limitations of membrane tethering. In particular, the ligand binding regions of these proteins likely need to be maximally exposed. Here we show by means of atomistic simulations of membrane-bound CD2, a small cell adhesio...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Authors


More from this funder
Name:
Wellcome Trust
Funding agency for:
Davis, S
Grant:
MR/K01577X/1
More from this funder
Name:
Engineering and Physical Sciences Research Council
Funding agency for:
Eggeling, C
Davis, S
Grant:
MR/K01577X/1
MR/K01577X/1
More from this funder
Name:
Biotechnology and Biological Sciences Research Council
Funding agency for:
Eggeling, C
Davis, S
Grant:
MR/K01577X/1
MR/K01577X/1
More from this funder
Name:
Medical Research Council
Funding agency for:
Eggeling, C
Davis, S
Grant:
MR/K01577X/1
MR/K01577X/1
More from this funder
Name:
European Research Council
Grant:
CROWDED-PRO-LIPIDS
Publisher:
American Chemical Society
Journal:
Journal of Physical Chemistry Letters More from this journal
Volume:
8
Issue:
5
Pages:
1060-1066
Publication date:
2017-02-01
Acceptance date:
2017-02-13
DOI:
EISSN:
1948-7185
Language:
English
Keywords:
Pubs id:
pubs:679962
UUID:
uuid:6a3492bc-d441-4ae6-88f0-5e27330eb0e4
Local pid:
pubs:679962
Source identifiers:
679962
Deposit date:
2017-03-18

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP