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Cutting edge: nonglycosidic CD1d lipid ligands activate human and murine invariant NKT cells.

Abstract:

Invariant NKT cells (iNKT cells) recognize CD1d/glycolipid complexes. We demonstrate that the nonglycosidic compound threitolceramide efficiently activates iNKT cells, resulting in dendritic cell (DC) maturation and the priming of Ag-specific T and B cells. Threitolceramide-pulsed DCs are more resistant to iNKT cell-dependent lysis than alpha-galactosylceramide-pulsed DCs due to the weaker affinity of the human iNKT TCR for CD1d/ threitolceramide than CD1d/alpha-galactosylceramide complexes. ...

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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
180
Issue:
10
Pages:
6452-6456
Publication date:
2008-05-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:6a30df8d-bc21-4f24-b171-eb1fc3776da5
Source identifiers:
21316
Local pid:
pubs:21316

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