- Abstract:
-
Invariant NKT cells (iNKT cells) recognize CD1d/glycolipid complexes. We demonstrate that the nonglycosidic compound threitolceramide efficiently activates iNKT cells, resulting in dendritic cell (DC) maturation and the priming of Ag-specific T and B cells. Threitolceramide-pulsed DCs are more resistant to iNKT cell-dependent lysis than alpha-galactosylceramide-pulsed DCs due to the weaker affinity of the human iNKT TCR for CD1d/ threitolceramide than CD1d/alpha-galactosylceramide complexes. ...
Expand abstract - Publisher copy:
- 10.4049/jimmunol.180.10.6452
-
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- Journal:
- Journal of immunology (Baltimore, Md. : 1950)
- Volume:
- 180
- Issue:
- 10
- Pages:
- 6452-6456
- Publication date:
- 2008-05-05
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- URN:
-
uuid:6a30df8d-bc21-4f24-b171-eb1fc3776da5
- Source identifiers:
-
21316
- Local pid:
- pubs:21316
- Language:
- English
- Keywords:
- Copyright date:
- 2008
Journal article
Cutting edge: nonglycosidic CD1d lipid ligands activate human and murine invariant NKT cells.
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