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Architecture of the major component of the type III secretion system export apparatus.

Abstract:

Type III secretion systems (T3SSs) are bacterial membrane-embedded nanomachines designed to export specifically targeted proteins from the bacterial cytoplasm. Secretion through T3SS is governed by a subset of inner membrane proteins termed the 'export apparatus'. We show that a key member of the Shigella flexneri export apparatus, MxiA, assembles into a ring essential for secretion in vivo. The ring-forming interfaces are well-conserved in both nonflagellar and flagellar homologs, implying t...

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Publication status:
Published

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Publisher copy:
10.1038/nsmb.2452

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Vergara-Irigaray, M More by this author
Johnson, S More by this author
Hendrixson, DR More by this author
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Journal:
Nature structural and molecular biology
Volume:
20
Issue:
1
Pages:
99-104
Publication date:
2013-01-05
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
URN:
uuid:6a304eb1-f3d2-4742-8172-8665f5274589
Source identifiers:
366134
Local pid:
pubs:366134

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