Journal article
Specifying the target difference in the primary outcome for a randomised controlled trial: guidance for researchers.
- Abstract:
-
BACKGROUND: Central to the design of a randomised controlled trial is the calculation of the number of participants needed. This is typically achieved by specifying a target difference and calculating the corresponding sample size, which provides reassurance that the trial will have the required statistical power (at the planned statistical significance level) to identify whether a difference of a particular magnitude exists. Beyond pure statistical or scientific concerns, it is ethically imp...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
+ Medical Research Council
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Funding agency for:
Cook, J
Grant:
G1002292
G0601938
Health Technology Assessment
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Bibliographic Details
- Publisher:
- BioMed Central Publisher's website
- Journal:
- Trials Journal website
- Volume:
- 16
- Issue:
- 1
- Pages:
- 526
- Publication date:
- 2015-12-01
- DOI:
- EISSN:
-
1745-6215
Item Description
- Language:
- English
- Pubs id:
-
pubs:506888
- UUID:
-
uuid:6a1d3ddb-e1e9-425c-adb7-420387c15517
- Local pid:
- pubs:506888
- Source identifiers:
-
506888
- Deposit date:
- 2015-12-01
Terms of use
- Copyright holder:
- Cook et al
- Copyright date:
- 2015
- Notes:
-
Copyright © 2015 Cook et al.; licensee BioMed Central.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Licence:
- CC Attribution (CC BY)
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