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Molecular imaging with optical coherence tomography using ligand-conjugated microparticles that detect activated endothelial cells: rational design through target quantification.

Abstract:

OBJECTIVES: Optical coherence tomography (OCT) is a high resolution imaging technique used to assess superficial atherosclerotic plaque morphology. Utility of OCT may be enhanced by contrast agents targeting molecular mediators of inflammation. METHODS AND RESULTS: Microparticles of iron oxide (MPIO; 1 and 4.5 μm diameter) in suspension were visualized and accurately quantified using a clinical optical coherence tomography system. Bound to PECAM-1 on a plane of cultured endothelial cells unde...

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Publication status:
Published

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Journal:
Atherosclerosis More from this journal
Volume:
219
Issue:
2
Pages:
579-587
Publication date:
2011-12-01
DOI:
EISSN:
1879-1484
ISSN:
0021-9150

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