- Abstract:
-
Methicillin-resistant Staphylococcus aureus (MRSA) poses a major threat to human health, particularly through hospital acquired infection. The spread of MRSA means that novel targets are required to develop potential inhibitors to combat infections caused by such drug-resistant bacteria. Thymidylate kinase (TMK) is attractive as an antibacterial target as it is essential for providing components for DNA synthesis. Here, we report crystal structures of unliganded and thymidylate-bound forms of...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1110/ps.052002406
-
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- Journal:
- Protein science : a publication of the Protein Society
- Volume:
- 15
- Issue:
- 4
- Pages:
- 774-784
- Publication date:
- 2006-04-05
- DOI:
- EISSN:
-
1469-896X
- ISSN:
-
0961-8368
- URN:
-
uuid:6a1b7a82-28a2-4a43-bdc3-efc3f760bfc6
- Source identifiers:
-
72630
- Local pid:
- pubs:72630
- Copyright date:
- 2006
Journal article
Structures of S. aureus thymidylate kinase reveal an atypical active site configuration and an intermediate conformational state upon substrate binding.
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