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Combined influence of B-cell receptor rearrangement and somatic hypermutation on B-cell class-switch fate in health and in chronic lymphocytic leukemia

Abstract:

A diverse B-cell receptor (BCR) repertoire is required to bind a wide range of antigens. BCRs are generated through genetic recombination and can be diversified through somatic hypermutation (SHM) or class-switch recombination (CSR). Patterns of repertoire diversity can vary substantially between different health conditions. We use isotype-resolved BCR sequencing to compare B-cell evolution and class-switch fate in healthy individuals and in patients with chronic lymphocytic leukemia (CLL). W...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0003-4337-8022
Publisher:
Frontiers Media
Journal:
Frontiers in Immunology More from this journal
Volume:
9
Issue:
2018
Pages:
1784
Publication date:
2018-08-10
Acceptance date:
2018-07-19
DOI:
EISSN:
1664-3224
ISSN:
1664-3224
Pmid:
30147686
Language:
English
Keywords:
Pubs id:
pubs:935381
UUID:
uuid:6a0d131b-1722-4831-8b5f-70a042cf072c
Local pid:
pubs:935381
Source identifiers:
935381
Deposit date:
2019-05-08

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