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Omega-3 Fatty Acid Status Enhances the Prevention of Cognitive Decline by B Vitamins in Mild Cognitive Impairment

Abstract:

A randomized trial (VITACOG) in people with mild cognitive impairment (MCI) found that B vitamin treatment to lower homocysteine slowed the rate of cognitive and clinical decline. We have used data from this trial to see whether baseline omega-3 fatty acid status interacts with the effects of B vitamin treatment. 266 participants with MCI aged ≥70 years were randomized to B vitamins (folic acid, vitamins B6 and B12) or placebo for 2 years. Baseline cognitive test performance, clinical dementi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3233/JAD-150777

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Publisher:
IOS Press Publisher's website
Journal:
Journal of Alzheimer's disease : JAD Journal website
Volume:
50
Issue:
2
Pages:
547-557
Publication date:
2016-01-01
Acceptance date:
2015-10-26
DOI:
ISSN:
1387-2877 and 1875-8908
Pmid:
26757190
Language:
English
Keywords:
Pubs id:
pubs:600470
UUID:
uuid:6a0c6806-1ae2-42fe-b36f-aa36b232a69e
Local pid:
pubs:600470
Deposit date:
2016-12-18

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